Solubility, Permeability, Anti-Inflammatory Action and In Vivo Pharmacokinetic Properties of Several Mechanochemically Obtained Pharmaceutical Solid Dispersions of Nimesulide

Solubility, Permeability, Anti-Inflammatory Action and In Vivo Pharmacokinetic Properties of Several Mechanochemically Obtained Pharmaceutical Solid Dispersions of Nimesulide

Nimesulide (NIM, <i>N</i>-(4-nitro-2-phenoxyphenyl)methanesulfonamide) is a relatively new nonsteroidal anti-inflammatory analgesic drug. It is practically insoluble in water (<0.02 mg/mL). This very poor aqueous solubility of the drug may lead to low bioavailability. The objective of...

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Bibliographic Details
Main Authors: Wei Wei, Veronica I. Evseenko, Mikhail V. Khvostov, Sergey A. Borisov, Tatyana G. Tolstikova, Nikolay E. Polyakov, Aleksandr V. Dushkin, Wenhao Xu, Lu Min, Weike Su
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
nimesulide
solid pharmaceutical dispersions
supramolecular complexes
micelles
disodium salt of glycyrrhizic acid
polysaccharide arabinogalactan
Online Access:https://www.mdpi.com/1420-3049/26/6/1513

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https://www.mdpi.com/1420-3049/26/6/1513

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