Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

Transient receptor potential melastatin 3 (TRPM3) channels are activated by heat, and chemical ligands such as pregnenolone sulphate (PregS) and CIM0216. Here, we show that activation of receptors coupled to heterotrimeric Gi/o proteins inhibits TRPM3 channels. This inhibition was alleviated by co-e...

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Bibliographic Details
Main Authors: Doreen Badheka, Yevgen Yudin, Istvan Borbiro, Cassandra M Hartle, Aysenur Yazici, Tooraj Mirshahi, Tibor Rohacs
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
TRPM3
G-protein
sensory ion channel
DRG neuron
TRPA1
TRPM8
Online Access:https://elifesciences.org/articles/26147

Internet

https://elifesciences.org/articles/26147

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