Neuroprotective Potential of L-Glutamate Transporters in Human Induced Pluripotent Stem Cell-Derived Neural Cells against Excitotoxicity

Neuroprotective Potential of L-Glutamate Transporters in Human Induced Pluripotent Stem Cell-Derived Neural Cells against Excitotoxicity

Human induced pluripotent stem cell (hiPSC)-derived neural cells have started to be used in safety/toxicity tests at the preclinical stage of drug development. As previously reported, hiPSC-derived neurons exhibit greater tolerance to excitotoxicity than those of primary cultures of rodent neurons;...

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Bibliographic Details
Main Authors: Kanako Takahashi, Yuto Ishibashi, Kaori Chujo, Ikuro Suzuki, Kaoru Sato
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
excitotoxicity
human induced pluripotent stem cell
neuron
astrocyte
L-glutamate transporter
EAAT1
Online Access:https://www.mdpi.com/1422-0067/24/16/12605

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https://www.mdpi.com/1422-0067/24/16/12605

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