mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice.

mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice.

Inhibitory glycinergic transmission in adult spinal cord is primarily mediated by glycine receptors (GlyRs) containing the α1 subunit. Here, we found that α1ins, a longer α1 variant with 8 amino acids inserted into the intracellular large loop (IL) between transmembrane (TM)3 and TM4 domains, was ex...

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Bibliographic Details
Main Authors: Zi-Yang Zhang, Hu-Hu Bai, Zhen Guo, Hu-Ling Li, Yong-Tao He, Xing-Lian Duan, Zhan-Wei Suo, Xian Yang, Yong-Xing He, Xiao-Dong Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000371

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https://doi.org/10.1371/journal.pbio.3000371

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