Optimization of a Method to Detect Autoantigen-Specific T-Cell Responses in Type 1 Diabetes

Optimization of a Method to Detect Autoantigen-Specific T-Cell Responses in Type 1 Diabetes

The development of tolerizing therapies aiming to inactivate autoreactive effector T-cells is a promising therapeutic approach to control undesired autoimmune responses in human diseases such as Type 1 Diabetes (T1D). A critical issue is a lack of sensitive and reproducible methods to analyze antige...

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Bibliographic Details
Main Authors: Yassmin Musthaffa, Hendrik J. Nel, Nishta Ramnoruth, Swati Patel, Emma E. Hamilton-Williams, Mark Harris, Ranjeny Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
proliferation
proinsulin
CD4+ T-cells
5,6-carboxylfluorescein diacetate succinimidyl ester
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.587469/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.587469/full

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