Untargeted Lipidomic Approach for Studying Different Nervous System Tissues of the Murine Model of Krabbe Disease

Untargeted Lipidomic Approach for Studying Different Nervous System Tissues of the Murine Model of Krabbe Disease

Krabbe disease is a rare neurodegenerative disease with an autosomal recessive character caused by a mutation in the <i>GALC</i> gene. The mutation leads to an accumulation of psychosine and a subsequent degeneration of oligodendrocytes and Schwann cells. Psychosine is the main biomarker...

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Bibliographic Details
Main Authors: Husam B. R. Alabed, Ambra Del Grosso, Valeria Bellani, Lorena Urbanelli, Sara Carpi, Miriam De Sarlo, Lorenzo Bertocci, Laura Colagiorgio, Sandra Buratta, Luca Scaccini, Dorotea Frongia Mancini, Ilaria Tonazzini, Marco Cecchini, Carla Emiliani, Roberto Maria Pellegrino
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biomolecules
Subjects:
lipidomics
LC/MS
Krabbe disease
psychosine
Twitcher mouse
untargeted mass spectrometry
Online Access:https://www.mdpi.com/2218-273X/13/10/1562

Internet

https://www.mdpi.com/2218-273X/13/10/1562

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