Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation

Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation

A number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by CD28 or CTLA4 and link this to cellular control of...

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Bibliographic Details
Main Authors: Simon Zenke, Mauricio P. Sica, Florian Steinberg, Julia Braun, Alicia Zink, Alina Gavrilov, Alexander Hilger, Aditya Arra, Monika Brunner-Weinzierl, Roland Elling, Niklas Beyersdorf, Tim Lämmermann, Cristian R. Smulski, Jan C. Rohr
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34156-1

Internet

https://doi.org/10.1038/s41467-022-34156-1

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