Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation
A number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by CD28 or CTLA4 and link this to cellular control of...
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Bibliographic Details
Main Authors: |
Simon Zenke,
Mauricio P. Sica,
Florian Steinberg,
Julia Braun,
Alicia Zink,
Alina Gavrilov,
Alexander Hilger,
Aditya Arra,
Monika Brunner-Weinzierl,
Roland Elling,
Niklas Beyersdorf,
Tim Lämmermann,
Cristian R. Smulski,
Jan C. Rohr |
Format: | Article
|
Language: | English |
Published: |
Nature Portfolio
2022-10-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-022-34156-1
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