Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation
A number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by CD28 or CTLA4 and link this to cellular control of...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34156-1 |
| _version_ | 1811192376257937408 |
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| author | Simon Zenke Mauricio P. Sica Florian Steinberg Julia Braun Alicia Zink Alina Gavrilov Alexander Hilger Aditya Arra Monika Brunner-Weinzierl Roland Elling Niklas Beyersdorf Tim Lämmermann Cristian R. Smulski Jan C. Rohr |
| author_facet | Simon Zenke Mauricio P. Sica Florian Steinberg Julia Braun Alicia Zink Alina Gavrilov Alexander Hilger Aditya Arra Monika Brunner-Weinzierl Roland Elling Niklas Beyersdorf Tim Lämmermann Cristian R. Smulski Jan C. Rohr |
| author_sort | Simon Zenke |
| collection | DOAJ |
| description | A number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by CD28 or CTLA4 and link this to cellular control of costimulation. |
| first_indexed | 2024-04-11T23:51:41Z |
| format | Article |
| id | doaj.art-36d473209bd24a689eb077a758720e5b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T23:51:41Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-36d473209bd24a689eb077a758720e5b2022-12-22T03:56:28ZengNature PortfolioNature Communications2041-17232022-10-0113111810.1038/s41467-022-34156-1Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulationSimon Zenke0Mauricio P. Sica1Florian Steinberg2Julia Braun3Alicia Zink4Alina Gavrilov5Alexander Hilger6Aditya Arra7Monika Brunner-Weinzierl8Roland Elling9Niklas Beyersdorf10Tim Lämmermann11Cristian R. Smulski12Jan C. Rohr13Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-UniversityMedical Physics Department, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Center for Biological Systems Analysis, Albert-Ludwigs-University FreiburgInstitute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-UniversityInstitute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-UniversityImmune Cell Dynamics Group, Max Planck Institute of Immunobiology and EpigeneticsDepartment of Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, Albert-Ludwigs-UniversityDepartment of Experimental Pediatrics and Neonatology and Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-UniversityDepartment of Experimental Pediatrics and Neonatology and Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-UniversityDepartment of Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, Albert-Ludwigs-UniversityInstitute of Virology and Immunobiology, University of WürzburgImmune Cell Dynamics Group, Max Planck Institute of Immunobiology and EpigeneticsMedical Physics Department, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-UniversityA number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by CD28 or CTLA4 and link this to cellular control of costimulation.https://doi.org/10.1038/s41467-022-34156-1 |
| spellingShingle | Simon Zenke Mauricio P. Sica Florian Steinberg Julia Braun Alicia Zink Alina Gavrilov Alexander Hilger Aditya Arra Monika Brunner-Weinzierl Roland Elling Niklas Beyersdorf Tim Lämmermann Cristian R. Smulski Jan C. Rohr Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation Nature Communications |
| title | Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation |
| title_full | Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation |
| title_fullStr | Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation |
| title_full_unstemmed | Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation |
| title_short | Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation |
| title_sort | differential trafficking of ligands trogocytosed via cd28 versus ctla4 promotes collective cellular control of co stimulation |
| url | https://doi.org/10.1038/s41467-022-34156-1 |
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