Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation
A number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by CD28 or CTLA4 and link this to cellular control of...
Main Authors: | Simon Zenke, Mauricio P. Sica, Florian Steinberg, Julia Braun, Alicia Zink, Alina Gavrilov, Alexander Hilger, Aditya Arra, Monika Brunner-Weinzierl, Roland Elling, Niklas Beyersdorf, Tim Lämmermann, Cristian R. Smulski, Jan C. Rohr |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-34156-1 |
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