Comprehensive Analysis of the 5xFAD Mouse Model of Alzheimer’s Disease Using dMRI, Immunohistochemistry, and Neuronal and Glial Functional Metabolic Mapping

Comprehensive Analysis of the 5xFAD Mouse Model of Alzheimer’s Disease Using dMRI, Immunohistochemistry, and Neuronal and Glial Functional Metabolic Mapping

Alzheimer’s disease (AD) is characterized by complex interactions between neuropathological markers, metabolic dysregulation, and structural brain changes. In this study, we utilized a multimodal approach, combining immunohistochemistry, functional metabolic mapping, and microstructure sensitive dif...

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Bibliographic Details
Main Authors: Emil W. Westi, Saba Molhemi, Caroline Termøhlen Hansen, Christian Stald Skoven, Rasmus West Knopper, Dashne Amein Ahmad, Maja B. Rindshøj, Aishat O. Ameen, Brian Hansen, Kristi A. Kohlmeier, Blanca I. Aldana
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biomolecules
Subjects:
Alzheimer’s disease
5xFAD mouse
amyloid-beta
gliosis
white mater degeneration
astrocytes
Online Access:https://www.mdpi.com/2218-273X/14/10/1294

Internet

https://www.mdpi.com/2218-273X/14/10/1294

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