Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts
Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | AppliedMath |
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| Online Access: | https://www.mdpi.com/2673-9909/4/1/10 |
| _version_ | 1797242263491837952 |
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| author | Frederika Rentzeperis Benjamin Coleman Dorothy Wallace |
| author_facet | Frederika Rentzeperis Benjamin Coleman Dorothy Wallace |
| author_sort | Frederika Rentzeperis |
| collection | DOAJ |
| description | Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell synchronization. The simulations offered in this study support the statement that, at suitably high levels of radiation, synchronizing melanoma cells with gemcitabine before treatment substantially reduces the final tumor size. The improvement is statistically significant, and the effect size is noticeable, with the near suppression of growth at 8 Gray and 92% synchronization. |
| first_indexed | 2024-04-24T18:36:27Z |
| format | Article |
| id | doaj.art-36d696744aea4b6aa0e256f431980520 |
| institution | Directory Open Access Journal |
| issn | 2673-9909 |
| language | English |
| last_indexed | 2024-04-24T18:36:27Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | AppliedMath |
| spelling | doaj.art-36d696744aea4b6aa0e256f4319805202024-03-27T13:18:50ZengMDPI AGAppliedMath2673-99092024-02-014119721010.3390/appliedmath4010010Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma XenograftsFrederika Rentzeperis0Benjamin Coleman1Dorothy Wallace2Department of Mathematics, Dartmouth College, Hanover, NH 03755, USADepartment of Mathematics, Dartmouth College, Hanover, NH 03755, USADepartment of Mathematics, Dartmouth College, Hanover, NH 03755, USARadiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell synchronization. The simulations offered in this study support the statement that, at suitably high levels of radiation, synchronizing melanoma cells with gemcitabine before treatment substantially reduces the final tumor size. The improvement is statistically significant, and the effect size is noticeable, with the near suppression of growth at 8 Gray and 92% synchronization.https://www.mdpi.com/2673-9909/4/1/10melanomagemcitabinemathematical modelradiotherapy |
| spellingShingle | Frederika Rentzeperis Benjamin Coleman Dorothy Wallace Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts AppliedMath melanoma gemcitabine mathematical model radiotherapy |
| title | Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts |
| title_full | Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts |
| title_fullStr | Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts |
| title_full_unstemmed | Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts |
| title_short | Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts |
| title_sort | cell cycle synchronization prior to radiotherapy a mathematical model of the use of gemcitabine on melanoma xenografts |
| topic | melanoma gemcitabine mathematical model radiotherapy |
| url | https://www.mdpi.com/2673-9909/4/1/10 |
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