Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation

Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation

The generation of cartilage from progenitor cells for the purpose of cartilage repair is often hampered by hypertrophic differentiation of the engineered cartilaginous tissue caused by endochondral ossification. Since a healthy cartilage matrix contains high amounts of Aggrecan and COMP, we hypothes...

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Bibliographic Details
Main Authors: Marjolein M. J. Caron, Maarten P. F. Janssen, Laura Peeters, Dominik R. Haudenschild, Andy Cremers, Don A. M. Surtel, Lodewijk W. van Rhijn, Pieter J. Emans, Tim J. M. Welting
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
chondrocyte hypertrophy
endochondral ossification
COMP
aggrecan
periosteum
periosteal chondrogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.01036/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.01036/full

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