Altered endotoxin responsiveness in healthy children with Down syndrome

Altered endotoxin responsiveness in healthy children with Down syndrome

Abstract Background Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are impo...

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Bibliographic Details
Main Authors: Dean Huggard, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, Timothy Ronan Leahy, Orla Franklin, Ana Moreno, Ashanty M. Melo, Derek G. Doherty, Eleanor J. Molloy
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Immunology
Subjects:
Down syndrome
Inflammation
Endotoxin
Innate immunity
Immunomodulation
Online Access:http://link.springer.com/article/10.1186/s12865-018-0270-z

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http://link.springer.com/article/10.1186/s12865-018-0270-z

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