The TTN p. Tyr4418Ter mutation causes cardiomyopathy in human and mice.

The TTN p. Tyr4418Ter mutation causes cardiomyopathy in human and mice.

<h4>Objective</h4>To generate a mouse model carrying TTNtv Y4370* simulating the newly discovered human heterozygous nonsense TTNtv c.13254T>G (p.Tyr4418Ter) to supplement and improve the functional evidence of pathogenic mutation TTNtv c.13254T>G on the pathogenic type of dilated...

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Bibliographic Details
Main Authors: Wenqiang Sun, Xiaohui Liu, Laichun Song, Liang Tao, Kaisheng Lai, Hui Jiang, Hongyan Xiao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296802&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296802&type=printable

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