Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes

Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes

Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based nanoparticles and liposomes and compared their capability to enhance pentamidine...

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Bibliographic Details
Main Authors: Geofrey Omarch, Yunus Kippie, Shireen Mentor, Naushaad Ebrahim, David Fisher, Grace Murilla, Hulda Swai, Admire Dube
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Pentamidine
PCL nanoparticles
liposomes
blood brain barrier
transendothelial electrical resistance
Human African Trypanosomiasis
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1596923

Internet

https://www.tandfonline.com/doi/10.1080/21691401.2019.1596923

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