Tumor–Stromal Interactions in a Co-Culture Model of Human Pancreatic Adenocarcinoma Cells and Fibroblasts and Their Connection with Tumor Spread

Tumor–Stromal Interactions in a Co-Culture Model of Human Pancreatic Adenocarcinoma Cells and Fibroblasts and Their Connection with Tumor Spread

One key feature of pancreatic ductal adenocarcinoma (PDAC) is a dense desmoplastic reaction that has been recognized as playing important roles in metastasis and therapeutic resistance. We aim to study tumor–stromal interactions in an in vitro coculture model between human PDAC cells (Capan-1 or PL-...

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Bibliographic Details
Main Authors: Elena Prieto-García, C. Vanesa Díaz-García, Alba Agudo-López, Virginia Pardo-Marqués, Inés García-Consuegra, Sara Asensio-Peña, Marina Alonso-Riaño, Carlos Pérez, Carlos Gómez, Jorge Adeva, Luis Paz-Ares, José A. López-Martín, M. Teresa Agulló-Ortuño
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomedicines
Subjects:
pancreatic ductal adenocarcinoma
cancer-associated fibroblasts
cocultures
cytokines
extracellular vesicles
Online Access:https://www.mdpi.com/2227-9059/9/4/364

Internet

https://www.mdpi.com/2227-9059/9/4/364

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