An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway

An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway

Abstract Background Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction, long-term cognitive impairment, and increased morbidity and mortality. The current treatment for SAE is mainly symptomatic; the lack of specific treatment options and a poor understanding of the...

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Bibliographic Details
Main Authors: Yuqiang Liu, Han Yang, Nanbo Luo, Yifei Fu, Fang Qiu, Zhenglong Pan, Xiongjuan Li, Wenling Jian, Xinping Yang, Qingsheng Xue, Yan Luo, Buwei Yu, Zhiheng Liu
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
Fgr
Sirtuin 1
PGC-1α
Mitochondria
Sepsis-associated encephalopathy
Online Access:https://doi.org/10.1186/s12967-023-04345-7

Internet

https://doi.org/10.1186/s12967-023-04345-7

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