The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013). Here, we show by genome-wide in vivo ribosome profiling...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Carmela Sidrauski, Anna M McGeachy, Nicholas T Ingolia, Peter Walter
स्वरूप: लेख
भाषा:English
प्रकाशित: eLife Sciences Publications Ltd 2015-02-01
श्रृंखला:eLife
विषय:
integrated stress response
eIF2
unfolded protein response
ISRIB
protein synthesis
ribosome profiling
ऑनलाइन पहुंच:https://elifesciences.org/articles/05033

इंटरनेट

https://elifesciences.org/articles/05033

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