SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy

SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy

Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as Alzheimer’s disease and frontotemporal dementia. The alternative s...

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Bibliographic Details
Main Authors: Javier Andrés Muñiz, Carolina Lucía Facal, Leandro Urrutia, Ramiro Clerici-Delville, Ana Damianich, Juan E. Ferrario, Germán Falasco, María Elena Avale
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
MAPT
RNA therapy
Trans-Splicing
Dementia
FDG-microPET
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.951384/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.951384/full

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