SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy

SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy

Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as Alzheimer’s disease and frontotemporal dementia. The alternative s...

Full description

Bibliographic Details
Main Authors:	Javier Andrés Muñiz, Carolina Lucía Facal, Leandro Urrutia, Ramiro Clerici-Delville, Ana Damianich, Juan E. Ferrario, Germán Falasco, María Elena Avale
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Bioengineering and Biotechnology
Subjects:	MAPT RNA therapy Trans-Splicing Dementia FDG-microPET
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2022.951384/full

Similar Items

The Link Between Tau and Insulin Signaling: Implications for Alzheimer’s Disease and Other Tauopathies
by: Rafaella Araujo Gonçalves, et al.
Published: (2019-02-01)

Heritability in frontotemporal tauopathies
by: Shelley L. Forrest, et al.
Published: (2019-12-01)

Tauopathy and Movement Disorders—Unveiling the Chameleons and Mimics
by: Jacky Ganguly, et al.
Published: (2020-11-01)

Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis
by: Li Liu, et al.
Published: (2022-04-01)

Tau Isoforms: Gaining Insight into <i>MAPT</i> Alternative Splicing
by: Andrea Corsi, et al.
Published: (2022-12-01)

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
by: Geraldine Zimmer-Bensch, et al.
Published: (2021-11-01)

Cellular and pathological heterogeneity of primary tauopathies
by: Dah-eun Chloe Chung, et al.
Published: (2021-08-01)

Integrated analysis of the aging brain transcriptome and proteome in tauopathy
by: Carl Grant Mangleburg, et al.
Published: (2020-09-01)

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
by: Yuxing Xia, et al.
Published: (2020-06-01)

Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study
by: Hideomi Hamasaki, et al.
Published: (2019-12-01)

iPS Cell-Based Model for MAPT Haplotype as a Risk Factor for Human Tauopathies Identifies No Major Differences in TAU Expression
by: Tabea Strauß, et al.
Published: (2021-08-01)

MAPT subhaplotypes in corticobasal degeneration: assessing associations with disease risk, severity of tau pathology, and clinical features
by: Rebecca R. Valentino, et al.
Published: (2020-12-01)

MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer’s Disease Model Mice
by: ShinWoo Kang, et al.
Published: (2022-05-01)

Radiosynthesis and Tumor MicroPET/CT Imaging of 18F-Fluoroethoxylerianin, an 18F-Labeled Erianin Analogue
by: Hui Nie, et al.
Published: (2022-04-01)

Tau (MAPT) haplotypes in Jordan: new evidence on the Middle East as a melting-pot predating Neolithic migration
by: Almuthanna K. Alkaraki, et al.
Published: (2021-07-01)

Behavioral Abnormalities in Knockout and Humanized Tau Mice
by: Rafaella Araujo Gonçalves, et al.
Published: (2020-03-01)

Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU
by: Sarah Bachmann, et al.
Published: (2021-05-01)

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies
by: Amy Easton, et al.
Published: (2022-09-01)

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy
by: Daniel W. Sirkis, et al.
Published: (2023-07-01)

Erratum: Behavioral Abnormalities in Knockout and Humanized Tau Mice
by: Frontiers Production Office
Published: (2021-11-01)

Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer
by: Cornelia Schroeder, et al.
Published: (2019-03-01)

Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98
by: Lisa Diez, et al.
Published: (2022-03-01)

Preclinical validations of [18F]FPyPEGCBT-c(RGDfK): a 18F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis
by: Didier J. Colin, et al.
Published: (2016-10-01)

Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice
by: Asha Jacob, et al.
Published: (2019-05-01)

Molecular Mechanisms in the Pathogenesis of Alzheimer’s disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation
by: Masato Hasegawa
Published: (2016-04-01)

Generation of 17q21.31 duplication iPSC-derived neurons as a model for primary tauopathies
by: Laetitia Miguel, et al.
Published: (2022-05-01)

Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R
by: Alexander Sandberg, et al.
Published: (2020-12-01)

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
by: Matthew J. Benskey, et al.
Published: (2023-09-01)

de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia
by: Kunie Ando, et al.
Published: (2020-06-01)

A dual tracer [11C]PBR28 and [18F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia
by: Santhoshi P. Palandira, et al.
Published: (2022-11-01)

Frontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutations
by: Giacomina eRossi, et al.
Published: (2015-10-01)

Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau−/− mice
by: Mariana Vargas-Caballero, et al.
Published: (2017-04-01)

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway
by: Shanya Jiang, et al.
Published: (2021-09-01)

Knockdown of LncRNA MAPT-AS1 inhibites proliferation and migration and sensitizes cancer cells to paclitaxel by regulating MAPT expression in ER-negative breast cancers
by: Yiyuan Pan, et al.
Published: (2018-02-01)

Elongator promotes neuritogenesis via regulation of tau stability through acly activity
by: Michal Shilian, et al.
Published: (2022-10-01)

Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains
by: Thomas K. Karikari, et al.
Published: (2019-07-01)

Dynamic evolution and mechanism of myocardial glucose metabolism in different functional phenotypes of diabetic cardiomyopathy — a study based on 18 F-FDG microPET myocardial metabolic imaging
by: Xiaoliang Shao, et al.
Published: (2023-04-01)

Importance of Attenuation Correction (AC) for Small Animal PET Imaging
by: Henrik H. El Ali, et al.
Published: (2012-10-01)

MAPT promoter CpG island hypermethylation is associated with poor prognosis in patients with stage II colorectal cancer
by: Wang C, et al.
Published: (2019-08-01)

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
by: Noah Lubben, et al.
Published: (2024-03-01)