A rapid, semi-quantitative assay to screen for modulators of alpha-synuclein oligomerization ex vivo

A rapid, semi-quantitative assay to screen for modulators of alpha-synuclein oligomerization ex vivo

Alpha synuclein (αsyn) aggregates are associated with the pathogenesis of Parkinson’s disease and others related disorders. Although modulation of αsyn aggregation is an attractive therapeutic target, new powerful methodologies are desperately needed to facilitate in vivo screening of novel therapeu...

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Bibliographic Details
Main Authors: Marion eDelenclos, Teodora eTrendafilova, Daryl R Jones, Simon eMoussaud, Ann Marie eBaine, Mei eYue, Warren D Hirst, Pamela J McLean
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Neuroscience
Subjects:
alpha-Synuclein
oligomers
bioluminescence
protein-fragment complementation
viral vector model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00511/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00511/full

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