Hopf bifurcations in an atypical p53 protein oscillator model with discrete delay or distributed delay

Hopf bifurcations in an atypical p53 protein oscillator model with discrete delay or distributed delay

Human cells have a natural cancerous defense system, and p53 protein is at the core. It is well known that p53 relies on oscillatory dynamic behavior to perform tumor suppressor functions. However, the mechanism of its oscillation remains unclear. To reveal the effect of time lag on the onset of p53...

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Bibliographic Details
Main Authors: Nan Liu, Hongli Yang, Liangui Yang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Physics
Subjects:
p53 oscillator model
Hopf bifurcation
Functional differential equation
Local or non-local delay
Normalization and central manifold methods
Anti-cancer strategy
Online Access:http://www.sciencedirect.com/science/article/pii/S221137972301077X

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http://www.sciencedirect.com/science/article/pii/S221137972301077X

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