A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling

A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling

An optimal intranasal (IN) dose of human mesenchymal stem cell-derived extracellular vesicles (hMSC-EVs), 90 min post-traumatic brain injury (TBI), has been reported to prevent the evolution of acute neuroinflammation into chronic neuroinflammation resulting in the alleviation of long-term cognitive...

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Bibliographic Details
Main Authors: Maheedhar Kodali, Leelavathi N. Madhu, Roxanne L. Reger, Bojana Milutinovic, Raghavendra Upadhya, Sahithi Attaluri, Bing Shuai, Goutham Shankar, Ashok K. Shetty
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cyclic AMP response-element binding protein
extracellular vesicles
hippocampal neurogenesis
mesenchymal stem cells
synapse loss
traumatic brain injury
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1185883/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1185883/full

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