Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca2+ER perturbation in hepatocellular carcinoma

Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca2+ER perturbation in hepatocellular carcinoma

The well-known insulin-like growth factor 1 (IGF1)/IGF-1 receptor (IGF-1R) signaling pathway is overexpressed in many tumors, and is thus an attractive target for cancer treatment. However, results have often been disappointing due to crosstalk with other signals. Here, we report that IGF-1R signali...

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Bibliographic Details
Main Authors: Yanan Li, Keqin Li, Ting Pan, Qiaobo Xie, Yuyao Cheng, Xinfeng Wu, Rui Xu, Xiaohui Liu, Li Liu, Jiangming Gao, Wenmin Yuan, Xianjun Qu, Shuxiang Cui
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
IGF-1R
HCC
Endoplasmic reticulum (ER)
SERCA2
Ca2+ER perturbation
βarrestin-2 (β-arr2)
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001946

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http://www.sciencedirect.com/science/article/pii/S2211383523001946

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