Innate immune activation and aberrant function in the R6/2 mouse model and Huntington’s disease iPSC-derived microglia

Innate immune activation and aberrant function in the R6/2 mouse model and Huntington’s disease iPSC-derived microglia

Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease caused by CAG repeats in exon 1 of the HTT gene. A hallmark of HD along with other psychiatric and neurodegenerative diseases is alteration in the neuronal circuitry and synaptic loss. Microglia and peripheral inn...

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Bibliographic Details
Main Authors: Julien Gasser, Gaelle Gillet, Jorge S. Valadas, Laura Rouvière, Apoorva Kotian, Wenqiang Fan, James Keaney, Irena Kadiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
microglia
phagocytosis
migration
neuroinflammation
Huntington’s disease
dendritic spines
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1191324/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1191324/full

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