Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice

Abstract Background Alzheimer’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies. Yet, the direct link between natural τ expression on glia cell activity and Aβ remains unclear. While exper...

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Bibliographic Details
Main Authors: Dorit Farfara, Meital Sooliman, Limor Avrahami, Tabitha Grace Royal, Shoshik Amram, Lea Rozenstein-Tsalkovich, Dorit Trudler, Shani Blanga-Kanfi, Hagit Eldar-Finkelman, Jens Pahnke, Hanna Rosenmann, Dan Frenkel
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Neuroinflammation
Subjects:
Tau
Beta-amyloid
5xFAD
Mouse model
Astrocytes
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s12974-023-02823-9

Internet

https://doi.org/10.1186/s12974-023-02823-9

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