Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease

Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease

Abstract Background Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Impaired autophagy in plaque-associated microglia (PAM) has been reported to accelerate amyloid plaque deposition and cognitive impairment in AD pathogenesis. Recent evidence suggests that the transcr...

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Bibliographic Details
Main Authors: Xueting Wang, Yuqi Xie, Guijuan Chen, Yapeng Lu, Dan Wang, Li Zhu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer's disease
Transcription factor EB
Plaque-associated microglia
Beta-amyloid degradation
Autophagy
Online Access:https://doi.org/10.1186/s12974-023-02931-6

Internet

https://doi.org/10.1186/s12974-023-02931-6

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