Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice

Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice

Niemann-Pick type C1 disease (NPC1) is an inherited neurovisceral lipid storage disorder, hallmarked by the intracellular accumulation of unesterified cholesterol and glycolipids in endocytic organelles. Cells acquire cholesterol through exogenous uptake and endogenous biosynthesis. NPC1 participati...

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Bibliographic Details
Main Authors: Patrick C. Reid, Shigeki Sugii, Ta-Yuan Chang
Format: Article
Language:English
Published: Elsevier 2003-05-01
Series:Journal of Lipid Research
Subjects:
intracellular cholesterol trafficking
NPC disease
cholesterol biosynthesis
acyl-CoA:cholesterol acyltransferase
membrane recycling
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311470

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http://www.sciencedirect.com/science/article/pii/S0022227520311470

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