Liquid-liquid phase separation in DNA double-strand breaks repair

Abstract DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by exposure genome to ionizing radiation or genotoxic chemicals. DSBs are mainly repaired by homologous recombination (HR) and nonhomologous end joining (NHEJ). To repair DSBs, a large amount of DNA repair facto...

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Bibliographic Details
Main Authors: Yun-Long Wang, Wan-Wen Zhao, Jie Shi, Xiang-Bo Wan, Jian Zheng, Xin-Juan Fan
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06267-0