Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats
The possible protective effect of sitagliptin (SIT) against nephrotoxicity induced by a single dose 5-fluorouracil (5-FU) (150 mg/kg, i.p.) was investigated in rats. SIT treatment (5 and 10 mg/kg/day, p.o.) was given for 7 days, starting 5 days before 5-FU administration. Both SIT doses caused signi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2024-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/114441/download/pdf/ |
| _version_ | 1797290392214831104 |
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| author | Ahmed Hassan Al-Ghamdi Mervat Z. Mohamed Rabei M. Elbadry Amr A. Fouad |
| author_facet | Ahmed Hassan Al-Ghamdi Mervat Z. Mohamed Rabei M. Elbadry Amr A. Fouad |
| author_sort | Ahmed Hassan Al-Ghamdi |
| collection | DOAJ |
| description | The possible protective effect of sitagliptin (SIT) against nephrotoxicity induced by a single dose 5-fluorouracil (5-FU) (150 mg/kg, i.p.) was investigated in rats. SIT treatment (5 and 10 mg/kg/day, p.o.) was given for 7 days, starting 5 days before 5-FU administration. Both SIT doses caused significant reductions of serum creatinine and neutrophil gelatinase-associated lipocalin levels in rats received 5-FU. Both doses of SIT also significantly decreased malondialdehyde, tumor necrosis factor-α, interleukin-1β, nuclear factor-κB p65 (NF-κB p65), Bax/Bcl-2 ratio, and cleaved caspase-3 in kidneys of 5-FU-challenged rats. Additionally, SIT, at both doses, significantly increased renal total antioxidant capacity and nuclear factor erythroid 2related factor 2 (Nrf2) in rats received 5-FU. Besides, SIT markedly attenuated the 5-FU-induced histopathological kidney tissue injury in rats. It was concluded that SIT, at both doses, provided a significant nephroprotective effect in 5-FU-challenged rats, through its antioxidant, antiinflammatory, and antiapoptotic activities, and by modulating Nrf2 and NF-κB pathways. |
| first_indexed | 2024-03-07T19:20:47Z |
| format | Article |
| id | doaj.art-370f09ec151a4595a344de267fac2814 |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-03-07T19:20:47Z |
| publishDate | 2024-02-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-370f09ec151a4595a344de267fac28142024-02-29T10:41:25ZengPensoft PublishersPharmacia2603-557X2024-02-01711510.3897/pharmacia.71.e114441114441Kidney protective effect of sitagliptin in 5-fluorouracil-challenged ratsAhmed Hassan Al-Ghamdi0Mervat Z. Mohamed1Rabei M. Elbadry2Amr A. Fouad3Al-Baha UniversityMinia UniversityAl-Baha UniversityAl-Baha UniversityThe possible protective effect of sitagliptin (SIT) against nephrotoxicity induced by a single dose 5-fluorouracil (5-FU) (150 mg/kg, i.p.) was investigated in rats. SIT treatment (5 and 10 mg/kg/day, p.o.) was given for 7 days, starting 5 days before 5-FU administration. Both SIT doses caused significant reductions of serum creatinine and neutrophil gelatinase-associated lipocalin levels in rats received 5-FU. Both doses of SIT also significantly decreased malondialdehyde, tumor necrosis factor-α, interleukin-1β, nuclear factor-κB p65 (NF-κB p65), Bax/Bcl-2 ratio, and cleaved caspase-3 in kidneys of 5-FU-challenged rats. Additionally, SIT, at both doses, significantly increased renal total antioxidant capacity and nuclear factor erythroid 2related factor 2 (Nrf2) in rats received 5-FU. Besides, SIT markedly attenuated the 5-FU-induced histopathological kidney tissue injury in rats. It was concluded that SIT, at both doses, provided a significant nephroprotective effect in 5-FU-challenged rats, through its antioxidant, antiinflammatory, and antiapoptotic activities, and by modulating Nrf2 and NF-κB pathways.https://pharmacia.pensoft.net/article/114441/download/pdf/ |
| spellingShingle | Ahmed Hassan Al-Ghamdi Mervat Z. Mohamed Rabei M. Elbadry Amr A. Fouad Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats Pharmacia |
| title | Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats |
| title_full | Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats |
| title_fullStr | Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats |
| title_full_unstemmed | Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats |
| title_short | Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats |
| title_sort | kidney protective effect of sitagliptin in 5 fluorouracil challenged rats |
| url | https://pharmacia.pensoft.net/article/114441/download/pdf/ |
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