Human abdominal subcutaneous-derived active beige adipocytes carrying FTO rs1421085 obesity-risk alleles exert lower thermogenic capacity

Human abdominal subcutaneous-derived active beige adipocytes carrying FTO rs1421085 obesity-risk alleles exert lower thermogenic capacity

Introduction: White adipocytes store lipids, have a large lipid droplet and few mitochondria. Brown and beige adipocytes, which produce heat, are characterized by high expression of uncoupling protein (UCP) 1, multilocular lipid droplets, and large amounts of mitochondria. The rs1421085 T-to-C singl...

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Bibliographic Details
Main Authors: Attila Vámos, Rini Arianti, Boglárka Ágnes Vinnai, Rahaf Alrifai, Abhirup Shaw, Szilárd Póliska, Andrea Guba, Éva Csősz, István Csomós, Gábor Mocsár, Cecilia Lányi, Zoltán Balajthy, László Fésüs, Endre Kristóf
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
adipocytes
beige
obesity
FTO rs1421085
thermogenesis
UCP 1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1155673/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1155673/full

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