Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[<em>e</em>][1,4]oxazepin-2(3<em>H</em>)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro

Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[<em>e</em>][1,4]oxazepin-2(3<em>H</em>)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro

Acute myeloid leukemia (AML) is the most aggressive type of blood cancer, and there is a continued need for new treatments that are well tolerated and improve long-term survival rates in patients. Induction of differentiation has emerged as a promising alternative to conventional cytotoxic chemother...

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Bibliographic Details
Main Authors: Laia Josa-Culleré, Thomas J. Cogswell, Irene Georgiou, Morgan Jay-Smith, Thomas R. Jackson, Carole J. R. Bataille, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
acute myeloid leukemia
differentiation
phenotypic screen
CD11b
benzooxazepinones
Online Access:https://www.mdpi.com/1420-3049/26/21/6648

Internet

https://www.mdpi.com/1420-3049/26/21/6648

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