Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD<sub>2</sub>-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2

Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD<sub>2</sub>-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2

In contrast to T lymphocytes, natural killer (NK) cells do not require prior sensitization but are rapidly activated upon encountering virally infected or neoplastic cells. In addition, NK cells can be safely applied in an allogeneic setting, making them important effector cells for the development...

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Bibliographic Details
Main Authors: Malena Bodden, Aline Häcker, Jasmin Röder, Anne Kiefer, Congcong Zhang, Anita Bhatti, Jordi Pfeifer Serrahima, Evelyn Ullrich, Ines Kühnel, Winfried S. Wels
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
natural killer cells
NK-92
chimeric antigen receptor
GD<sub>2</sub>
interleukin-15
Online Access:https://www.mdpi.com/2072-6694/15/17/4310

Internet

https://www.mdpi.com/2072-6694/15/17/4310

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