Chimeric Antigen Receptor T-Cell Therapy in Paediatric B-Cell Precursor Acute Lymphoblastic Leukaemia: Curative Treatment Option or Bridge to Transplant?

Chimeric Antigen Receptor T-Cell Therapy in Paediatric B-Cell Precursor Acute Lymphoblastic Leukaemia: Curative Treatment Option or Bridge to Transplant?

Chimeric antigen receptor T-cell therapy (CAR-T) targeting CD19 has been associated with remarkable responses in paediatric patients and adolescents and young adults (AYA) with relapsed/refractory (R/R) B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Tisagenlecleucel, the first approved CD...

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Bibliographic Details
Main Authors: Jochen Buechner, Ignazio Caruana, Annette Künkele, Susana Rives, Kim Vettenranta, Peter Bader, Christina Peters, André Baruchel, Friso G. Calkoen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pediatrics
Subjects:
CAR (chimeric antigen receptor) T cells
child
haematopoietic stem cell transplantation
ALL (acute lymphoblastic leukaemia)
B-ALL
bridge to allogeneic stem cell transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.784024/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2021.784024/full

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