Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses

Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses

Abstract Background Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β) and other cytokines produced during inflammatory responses activate sensory neurons (nociceptors) to mediate the onset of pain, sickness beha...

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Bibliographic Details
Main Authors: Harold A. Silverman, Aisling Tynan, Tyler D. Hepler, Eric H. Chang, Manojkumar Gunasekaran, Jian Hua Li, Tomás S. Huerta, Tea Tsaava, Qing Chang, Meghan E. Addorisio, Adrian C. Chen, Dane A. Thompson, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Medicine
Subjects:
Neural anti-inflammatory response
TRPA1
Cytokines
Nociception
Online Access:https://doi.org/10.1186/s10020-022-00590-6

Internet

https://doi.org/10.1186/s10020-022-00590-6

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