Inhibiting Intestinal Krüppel-Like Factor 5 Impairs the Beneficial Role of Renal Denervation in Gut Microbiota in Rats with Heart Failure

Inhibiting Intestinal Krüppel-Like Factor 5 Impairs the Beneficial Role of Renal Denervation in Gut Microbiota in Rats with Heart Failure

ABSTRACT Krüppel-like factor 5 (KLF5) is critical in maintaining intestinal barrier function, and renal denervation (RDN) mitigates gut microbiota aberrations in rats with heart failure (HF). It is unclear whether intestinal KLF5 can be regulated by RDN and whether inhibiting intestinal KLF5 weakens...

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Bibliographic Details
Main Authors: Zhiqin Guo, Fuyan Chen, Yufeng Chen, Chao Liu, Shaonan Li, Pingan Chen
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
gut microbiota
heart failure
Krüppel-like factor 5
renal denervation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02183-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02183-22

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