SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway

SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway

Abstract Background Sestrin2 (SESN2), a stress-inducible protein, has been reported to protect against denervated muscle atrophy through unfolded protein response and mitophagy, while its role in myofiber type transition remains unknown. Methods A mouse sciatic nerve transection model was created to...

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Bibliographic Details
Main Authors: Xiaofan Yang, Pingping Xue, Zhenyu Liu, Wenqing Li, Chuyan Li, Zhenbing Chen
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
Denervation
Skeletal muscle atrophy
Myofiber type transition
SESN2
AMPK/PGC-1α
Online Access:https://doi.org/10.1186/s11658-022-00367-z

Internet

https://doi.org/10.1186/s11658-022-00367-z

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