Three-Dimensional Patient-Derived In Vitro Sarcoma Models: Promising Tools for Improving Clinical Tumor Management

Three-Dimensional Patient-Derived In Vitro Sarcoma Models: Promising Tools for Improving Clinical Tumor Management

Over the past decade, the development of new targeted therapeutics directed against specific molecular pathways involved in tumor cell proliferation and survival has allowed an essential improvement in carcinoma treatment. Unfortunately, the scenario is different for sarcomas, a group of malignant n...

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Bibliographic Details
Main Authors: Manuela Gaebler, Alessandra Silvestri, Johannes Haybaeck, Peter Reichardt, Caitlin D. Lowery, Louis F. Stancato, Gabriele Zybarth, Christian R. A. Regenbrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Oncology
Subjects:
sarcoma
preclinical model
in vitro organoid culture
patient-derived in vitro model
drug screening
sarcoma treatment
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00203/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2017.00203/full

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