Early Stage Alterations in White Matter and Decreased Functional Interhemispheric Hippocampal Connectivity in the 3xTg Mouse Model of Alzheimer’s Disease

Early Stage Alterations in White Matter and Decreased Functional Interhemispheric Hippocampal Connectivity in the 3xTg Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even before the appearance of the classical neuropathologic...

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Bibliographic Details
Main Authors: Francis A. M. Manno, Arturo G. Isla, Sinai H. C. Manno, Irfan Ahmed, Shuk Han Cheng, Fernando A. Barrios, Condon Lau
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease (AD)
3xTg-AD mouse model
diffusion tensor imaging (DTI)
resting-state functional magnetic resonance imaging (rsfMRI)
fractional anisotropy
radial diffusivity
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00039/full

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00039/full

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