<i>Naegleria fowleri</i> Cathepsin B Induces a Pro-Inflammatory Immune Response in BV-2 Microglial Cells via NF-κB and AP-1 Dependent-MAPK Signaling Pathway

<i>Naegleria fowleri</i> Cathepsin B Induces a Pro-Inflammatory Immune Response in BV-2 Microglial Cells via NF-κB and AP-1 Dependent-MAPK Signaling Pathway

<i>Naegleria fowleri</i> is a ubiquitous protozoa parasite that can cause primary amoebic meningoencephalitis (PAM), a fatal brain infection in humans. Cathepsin Bs of <i>N. fowleri</i> (NfCBs) are multifamily enzymes. Although their pathogenic mechanism in PAM is not clearly...

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Bibliographic Details
Main Authors: Hương Giang Lê, Jung-Mi Kang, Tuấn Cường Võ, Byoung-Kuk Na
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Naegleria fowleri</i>
cathepsin B cysteine protease
microglial cells
pro-inflammatory response
MAPK
NF-κB
Online Access:https://www.mdpi.com/1422-0067/23/15/8388

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https://www.mdpi.com/1422-0067/23/15/8388

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