Cardiomyopathies associated with the DES gene mutations: molecular pathogenesis and gene therapy approaches

Cardiomyopathies associated with the DES gene mutations: molecular pathogenesis and gene therapy approaches

Cardiomyopathy (CMP) is a common group of cardiovascular disorders. Genetic (primary) cardiomyopathies are related to abnormalities in more than 100 genes, including the DES gene encoding desmin protein. Desmin is an essential member of the intermediate filaments, ensuring the structural and functio...

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Bibliographic Details
Main Authors: K. S. Kochergin-Nikitsky, E. V. Zaklyazminskaya, A. V. Lavrov, S. A. Smirnikhina
Format: Article
Language:Russian
Published: MONIKI 2019-12-01
Series:Alʹmanah Kliničeskoj Mediciny
Subjects:
cardiomyopathy
desmin
desminopathy
medical genetics
gene therapy
genome editing
crispr/cas9
Online Access:https://www.almclinmed.ru/jour/article/view/1059

Internet

https://www.almclinmed.ru/jour/article/view/1059

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