Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice

Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice

The BRCA1-PALB2-BRCA2 axis, or the BRCA pathway, plays key roles in genome stability maintenance and suppression of breast and several other cancers. Due to frequent p53 mutations in human BRCA1 breast cancers and mouse mammary tumors from Brca1, Brca2 and Palb2 conditional knockout models, it is of...

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Bibliographic Details
Main Authors: Amar H. Mahdi, Yanying Huo, Ying Chen, Pier Selenica, Anchal Sharma, Elise Merritt, Nicola Barnard, Chang Chan, Shridar Ganesan, Jorge S. Reis-Filho, Britta Weigelt, Subhajyoti De, Bing Xia
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-05-01
Series:Genes and Diseases
Subjects:
BRCA1
BRCA2
Osteosarcoma
p53
PALB2
Thymic lymphoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220301173

Internet

http://www.sciencedirect.com/science/article/pii/S2352304220301173

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