BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer

BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer

Abstract Background Brother of regulator of imprinted sites (BORIS) is expressed in most cancers and often associated with short survival and poor prognosis in patients. BORIS inhibits apoptosis and promotes proliferation of cancer cells. However, its mechanism of action has not been elucidated, and...

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Bibliographic Details
Main Authors: Yanmei Zhang, Mengdie Fang, Shouye Li, Hao Xu, Juan Ren, Linglan Tu, Bowen Zuo, Wanxin Yao, Guang Liang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Molecular Cancer
Subjects:
BORIS
Targeted peptide
ADP-ribosylation
DNA damage
Non-small cell lung cancer
Online Access:https://doi.org/10.1186/s12943-022-01621-w

Internet

https://doi.org/10.1186/s12943-022-01621-w

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