Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives

Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives

Co-expression of the epidermal growth factor receptor (EGFR, also known as ErbB1) and human epidermal growth factor receptor 2 (HER2) has been identified as a diagnostic or prognostic sign in various tumors. Despite the fact that lapatinib (EGFR/HER2 dual inhibitor) has shown to be successful, many...

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Bibliographic Details
Main Authors: Ahmed Elkamhawy, Seohyun Son, Hwa Young Lee, Mahmoud H. El-Maghrabey, Mohamed A. El Hamd, Saud O. Alshammari, Abeer A. Abdelhameed, Qamar A. Alshammari, Ahmed Abdeen, Samah F. Ibrahim, Wael A. Mahdi, Sultan Alshehri, Radwan Alnajjar, Won Jun Choi, Ahmed A. Al-Karmalawy, Kyeong Lee
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceuticals
Subjects:
nitro group containing drugs
antiproliferative activity
EGFR/HER2 dual inhibition
synthesis
kinase panel
lapatinib
Online Access:https://www.mdpi.com/1424-8247/16/1/43

Internet

https://www.mdpi.com/1424-8247/16/1/43

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