New <i>N</i>-Adducts of Thiadiazole and Thiazoline with Levoglucosenone and Evaluation of Their Significant Cytotoxic (Anti-Cancer) Activity

The conjugate N-adducts of thio-1,3,4-diazole and 2-thiazoline with levoglucosenone were synthesized via a stereoselective, base-catalyzed conjugate N-Michael addition to levoglucosenone at C-4. Structural assignments were established using 1H and 13C NMR analysis, and X-ray single-crystal analysis...

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Bibliographic Details
Main Authors: Tomasz Poplawski, Grzegorz Galita, Joanna Sarnik, Anna Macieja, Roman Bielski, Donald E. Mencer, Zbigniew J. Witczak
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/16/1/216