Antinociceptive effect of LMH-2, a new sigma-1 receptor antagonist analog of haloperidol, on the neuropathic pain of diabetic mice

Antinociceptive effect of LMH-2, a new sigma-1 receptor antagonist analog of haloperidol, on the neuropathic pain of diabetic mice

This study evaluates the antiallodynic and antihyperalgesic effects of LMH-2, a new haloperidol (HAL) analog that acts as sigma-1 receptor (σ1 R) antagonist, in diabetic mice using a model of neuropathic pain induced by chronic hyperglycemia. Additionally, we compared its effects with those of HAL....

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Bibliographic Details
Main Authors: Rosa Ventura-Martínez, Guadalupe Esther Ángeles-López, Diana González-Ugalde, Tania Domínguez-Páez, Gabriel Navarrete-Vázquez, Ruth Jaimez, Myrna Déciga-Campos
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
LMH-2
sigma-1 receptor
antiallodynic effect
antihyperalgesic effect
neuropathic pain
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224004086

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http://www.sciencedirect.com/science/article/pii/S0753332224004086

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