Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta

Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta

IntroductionTumour-reactive T cells producing the B-cell attractant chemokine CXCL13, in solid tumours, promote development of tertiary lymphoid structures (TLS) and are associated with improved prognosis and responsiveness to checkpoint immunotherapy. Cancer associated fibroblasts are the dominant...

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Bibliographic Details
Main Authors: Richard A. O’Connor, Begoña Roman Martinez, Lilian Koppensteiner, Layla Mathieson, Ahsan R. Akram
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
cancer associated fibroblast
T cell
CXCL13
Treg
non-small cell lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1221532/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1221532/full

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