Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells

Gastric cancer is one of the leading causes of cancer-related deaths. Chemotherapy has improved long-term survival of patients with gastric cancer. Unfortunately, cancer readily develops resistance to apoptosis-inducing agents. New mechanisms, inducing caspase-independent paraptosis-like cell death...

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Bibliographic Details
Main Authors: Xi Chen, Xiaoming Chen, Xi Zhang, Li Wang, Peihai Cao, Vinothkumar Rajamanickam, Chao Wu, Huiping Zhou, Yuepiao Cai, Guang Liang, Yi Wang
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718308711