Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway

Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway

Abstract Background Intestinal ischemia/reperfusion (I/R) injury commonly occurs during perioperative periods, resulting in high morbidity and mortality on a global scale. Dexmedetomidine (Dex) is a selective α2-agonist that is frequently applied during perioperative periods for its analgesia effect...

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Bibliographic Details
Main Authors: Qin Zhang, Xiao-Ming Liu, Qian Hu, Zheng-Ren Liu, Zhi-Yi Liu, Huai-Gen Zhang, Yuan-Lu Huang, Qiu-Hong Chen, Wen-Xiang Wang, Xue-Kang Zhang
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Translational Medicine
Subjects:
Intestinal ischemia/reperfusion injury
Dexmedetomidine
Enteric glial cells
Mitochondria damage
Apoptosis
Online Access:https://doi.org/10.1186/s12967-021-03027-6

Internet

https://doi.org/10.1186/s12967-021-03027-6

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